| 세션명 | 의료용 고분자 부문위원회(III) |
|---|---|
| 발표장 | 포스터장 |
| 논문코드 | 3PS-304 |
| 발표일 | 2018-10-12 |
| 발표시간 | 16:00-17:30 (게시시간: 14:00-17:30) |
| 논문제목 | Drug-Delivery Nano-carrier based on Nitrilotriacetic Acid-End-Functionalized Poly(ε-caprolactone) |
| 발표자 | 황아란 |
| 발표자 소속 | 부산대학교 |
| 저자 | 황아란, 이채연, leeja jose, 심규환1, 안성수1, 백현종† |
| 소속 | 부산대학교; 1가천대학교 |
| 논문초록 | Polymer-protein core-shell hybrid structures are in the limelight as the new generation of nanocarriers due to the biocompatibility of proteins and the versatile functionalities of proteins. Here, we developed the protein-polymer nano-carriers by using nickel-complexed nitrilotriacetic acid-end-functionalized polycaprolactone (Ni-NTA-PCL) to apply drug-delivery system. Ni-NTA-PCL was prepared using a initiator containing NTA moiety via ring-opening polymerization. The GFP/PCL nano-carriers loaded with doxorubicin (DOX) (GFP/PCL-DOX) were constructed by adding DMF solution containing Ni2+-NTA-PCL and DOX to a phosphate buffer solution containing His6-GFP. DOX and PCL aggregated in water due to hydrophobic effects and His6-GFP was conjugated to the PCL particle by complexation between the His tag and Ni-NTA. The potential of GFP/PCL-DOX as drug vehicle was verified by the cellular uptake and cytotoxicity test on neuroblastoma SH-SY5Y cell. |
THE POLYMER SOCIETY OF KOREA